Pengaruh Suhu dan Pengadukan terhadap Laju Disolusi Tablet Vitamin C

Abstract

Dissolution is a critical physicochemical process for oral solid dosage forms because drug release from tablets must occur before absorption. This study evaluated the effect of temperature and stirring on the simple dissolution rate of vitamin C tablets. The experiment used six treatments consisting of cold medium at 10 °C, room-temperature medium, and warm medium at 40 °C, each tested with and without stirring. Each treatment was performed in three replications using 100 mL medium, tablet mass measurement, stopwatch observation, and calculation of simple dissolution rate from tablet mass divided by complete dissolution time. The results showed that the longest dissolution time occurred in cold medium without stirring (P1), with an average dissolution time of 4,414 s and a dissolution rate of 0.056 mg/s. The fastest dissolution occurred in warm medium with stirring (P6), with an average dissolution time of 291 s and a dissolution rate of 0.869 mg/s. These findings indicate that higher temperature and stirring accelerate tablet dissolution by increasing molecular motion and reducing the stagnant diffusion layer around the tablet surface. The study concludes that temperature and stirring are dominant physical factors affecting simple dissolution behavior of vitamin C tablets.